Assay Detail
Binding
CHEMBL4834060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs by ELISA
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-<i>N</i>-(2'-methyl-3'-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)benzamide. Structure-Activity Relationship and Preclinical Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.23 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857063 | — | — | 1 | 8.10 |
| CHEMBL4868242 | — | — | 1 | 7.96 |
| CHEMBL4869725 | — | — | 1 | 7.85 |
| CHEMBL4868367 | — | — | 1 | 7.50 |
| CHEMBL4848840 | — | — | 1 | 7.47 |
| CHEMBL4861512 | — | — | 1 | 7.47 |
| CHEMBL4868517 | — | — | 1 | 7.30 |
| CHEMBL4859192 | — | — | 1 | 7.26 |
| CHEMBL4859714 | — | — | 1 | 7.19 |
| CHEMBL4855379 | — | — | 1 | 7.19 |
| CHEMBL4854994 | — | — | 1 | 7.16 |
| CHEMBL4872086 | — | — | 1 | 7.11 |
| CHEMBL4868543 | — | — | 1 | 7.03 |
| CHEMBL4848699 | — | — | 1 | 6.82 |
| CHEMBL4862512 | — | — | 1 | 6.77 |
| CHEMBL4874097 | — | — | 1 | 6.75 |
| CHEMBL4872805 | — | — | 1 | 6.64 |
| CHEMBL4871844 | — | — | 1 | 6.48 |
| CHEMBL4867119 | — | — | 1 | - |
| CHEMBL4879301 | — | — | 1 | - |
| CHEMBL4868782 | — | — | 1 | - |
| CHEMBL4859561 | — | — | 1 | - |
| CHEMBL4870286 | — | — | 1 | - |
| CHEMBL4864080 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857063 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4868242 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4869725 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4868367 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4848840 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4861512 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4868517 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4859192 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4859714 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4855379 | — | IC50 | = | 64.8 | nM | 7.19 |
| CHEMBL4854994 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4872086 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4868543 | — | IC50 | = | 94.4 | nM | 7.03 |
| CHEMBL4848699 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4862512 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL4874097 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL4872805 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL4871844 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL4867119 | — | IC50 | - | — | - | |
| CHEMBL4879301 | — | IC50 | - | — | - | |
| CHEMBL4868782 | — | IC50 | - | — | - | |
| CHEMBL4859561 | — | IC50 | - | — | - | |
| CHEMBL4870286 | — | IC50 | - | — | - | |
| CHEMBL4864080 | — | IC50 | - | — | - |