Compound Detail
CHEMBL4859714
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Basic Information
| ChEMBL ID | CHEMBL4859714 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NQLUEONWNDPITM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
423.4
MW (Da)
3.34
ALogP
7
HBA
1
HBD
102.9
PSA (Ų)
0.54
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Interleukin-2 CHEMBL5880 | IC50 | 7.19 | 7.19 | 64.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Interleukin-2 | IC50 | = | 64.0 | nM | 7.19 | Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated ... | 34843241 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34843241 | 10.1021/acs.jmedchem.1c01403 | Interleukin-2 | 1 |
Data from ChEMBL 36 via Core Engine