Assay Detail
Functional
CHEMBL4835169
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Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 10.74 | 10.82 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3648356 | — | — | 1 | 10.82 |
| CHEMBL45 | MELATONIN | 4.0 | 2 | 10.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3648356 | — | EC50 | = | 0.015 | nM | 10.82 |
| CHEMBL45 | MELATONIN | EC50 | = | 0.022 | nM | 10.66 |
| CHEMBL45 | MELATONIN | Activity | - | — | - |