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Assay Detail

CHEMBL4835347

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of sGFP-p62-LIR peptide from human N-terminal SNAP-fused LC3A by time-resolved FRET assay
ChEMBL ↗
95
Total Activities
61
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Microtubule-associated proteins 1A/1B light chain 3A (CHEMBL4879518) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Demonstrating Ligandability of the LC3A and LC3B Adapter Interface.
Hartmann M, Huber J, Kramer JS, Heering J, Pietsch L, Stark H, Odadzic D, Bischoff I, Fürst R, Schröder M, Akutsu M, Chaikuad A, Dötsch V, Knapp S, Biondi RM, Rogov VV, Proschak E.
J Med Chem (2021) 64 : 3720 -3746
PubMed 33769048 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 61 4.64 5.48
IC50 34 4.30 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4851364 — — 2 5.48
CHEMBL4852281 — — 2 5.19
CHEMBL4861964 — — 2 5.14
CHEMBL4878621 — — 2 5.12
CHEMBL36506 NOVOBIOCIN 4.0 2 5.06
CHEMBL4878719 — — 2 5.06
CHEMBL4865071 — — 1 4.92
CHEMBL4856823 — — 1 4.92
CHEMBL4856665 — — 2 4.91
CHEMBL4875925 — — 1 4.89
CHEMBL4860932 — — 1 4.89
CHEMBL4851932 — — 2 4.88
CHEMBL4869659 — — 2 4.88
CHEMBL4859492 — — 2 4.82
CHEMBL4854132 — — 2 4.81
CHEMBL4875883 — — 2 4.75
CHEMBL4876524 — — 1 4.75
CHEMBL4873678 — — 2 4.72
CHEMBL4847717 — — 1 4.70
CHEMBL4877664 — — 1 4.70
CHEMBL4867942 — — 1 4.70
CHEMBL4853160 — — 2 4.66
CHEMBL4864565 — — 2 4.65
CHEMBL4864988 — — 2 4.61
CHEMBL4873913 — — 2 4.61
CHEMBL4860350 — — 1 4.58
CHEMBL4845679 — — 2 4.58
CHEMBL4851243 — — 1 4.50
CHEMBL4871486 — — 2 4.49
CHEMBL4879193 — — 1 4.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4851364 — Ki = 3300.0 nM 5.48
CHEMBL4852281 — Ki = 6400.0 nM 5.19
CHEMBL4861964 — Ki = 7200.0 nM 5.14
CHEMBL4878621 — Ki = 7500.0 nM 5.12
CHEMBL36506 NOVOBIOCIN Ki = 8800.0 nM 5.06
CHEMBL4878719 — Ki = 8800.0 nM 5.06
CHEMBL4865071 — Ki = 12000.0 nM 4.92
CHEMBL4856823 — Ki = 12000.0 nM 4.92
CHEMBL4856665 — Ki = 12300.0 nM 4.91
CHEMBL4875925 — Ki = 13000.0 nM 4.89
CHEMBL4860932 — Ki = 13000.0 nM 4.89
CHEMBL4851932 — Ki = 13300.0 nM 4.88
CHEMBL4869659 — Ki = 13200.0 nM 4.88
CHEMBL4859492 — Ki = 15000.0 nM 4.82
CHEMBL4854132 — Ki = 15600.0 nM 4.81
CHEMBL4851364 — IC50 = 16000.0 nM 4.80
CHEMBL4876524 — Ki = 18000.0 nM 4.75
CHEMBL4875883 — Ki = 17600.0 nM 4.75
CHEMBL4873678 — Ki = 18900.0 nM 4.72
CHEMBL4867942 — Ki = 20000.0 nM 4.70
CHEMBL4877664 — Ki = 20000.0 nM 4.70
CHEMBL4847717 — Ki = 20000.0 nM 4.70
CHEMBL4853160 — Ki = 21800.0 nM 4.66
CHEMBL4864565 — Ki = 22600.0 nM 4.65
CHEMBL4864988 — Ki = 24600.0 nM 4.61
CHEMBL4873913 — Ki = 24300.0 nM 4.61
CHEMBL4845679 — Ki = 26200.0 nM 4.58
CHEMBL4860350 — Ki = 26000.0 nM 4.58
CHEMBL4852281 — IC50 = 31200.0 nM 4.51
CHEMBL4851243 — Ki = 32000.0 nM 4.50
CHEMBL4871486 — Ki = 32700.0 nM 4.49
CHEMBL4861964 — IC50 = 35300.0 nM 4.45
CHEMBL4878621 — IC50 = 36700.0 nM 4.43
CHEMBL4872970 — Ki = 38900.0 nM 4.41
CHEMBL4879193 — Ki = 39000.0 nM 4.41
CHEMBL4849771 — Ki = 42000.0 nM 4.38
CHEMBL36506 NOVOBIOCIN IC50 = 42900.0 nM 4.37
CHEMBL4850282 — Ki = 43000.0 nM 4.37
CHEMBL4878719 — IC50 = 42800.0 nM 4.37
CHEMBL4865705 — Ki = 44000.0 nM 4.36
CHEMBL4878531 — Ki = 44000.0 nM 4.36
CHEMBL4876107 — Ki = 44000.0 nM 4.36
CHEMBL4855220 — Ki = 44300.0 nM 4.35
CHEMBL4853955 — Ki = 44800.0 nM 4.35
CHEMBL4867617 — Ki = 47000.0 nM 4.33
CHEMBL4851652 — Ki = 46900.0 nM 4.33
CHEMBL4858470 — Ki = 52000.0 nM 4.28
CHEMBL4868774 — Ki = 53000.0 nM 4.28
CHEMBL4856665 — IC50 = 59900.0 nM 4.22
CHEMBL4869659 — IC50 = 64400.0 nM 4.19