Assay Detail
Binding
CHEMBL4835417
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Agonist activity at human RXRgamma transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 39 | 5.64 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4855847 | — | — | 1 | 7.30 |
| CHEMBL4874191 | — | — | 1 | 6.70 |
| CHEMBL4855868 | — | — | 1 | 6.52 |
| CHEMBL4876667 | — | — | 1 | 6.52 |
| CHEMBL4879068 | — | — | 1 | 6.40 |
| CHEMBL4855407 | — | — | 1 | 6.34 |
| CHEMBL4854458 | — | — | 1 | 6.30 |
| CHEMBL4868343 | — | — | 1 | 5.89 |
| CHEMBL4872307 | — | — | 1 | 5.89 |
| CHEMBL4515740 | — | — | 1 | 5.85 |
| CHEMBL4852349 | — | — | 1 | 5.82 |
| CHEMBL4849999 | — | — | 1 | 5.82 |
| CHEMBL4862605 | — | — | 1 | 5.80 |
| CHEMBL4873606 | — | — | 1 | 5.80 |
| CHEMBL4849776 | — | — | 1 | 5.79 |
| CHEMBL4875485 | — | — | 1 | 5.72 |
| CHEMBL4446467 | — | — | 1 | 5.55 |
| CHEMBL4848283 | — | — | 1 | 5.52 |
| CHEMBL4867027 | — | — | 1 | 5.52 |
| CHEMBL4873831 | — | — | 1 | 5.50 |
| CHEMBL4866557 | — | — | 1 | 5.46 |
| CHEMBL4859732 | — | — | 1 | 5.46 |
| CHEMBL4865656 | — | — | 1 | 5.43 |
| CHEMBL4862395 | — | — | 1 | 5.40 |
| CHEMBL4471300 | — | — | 1 | 5.35 |
| CHEMBL4867317 | — | — | 1 | 5.22 |
| CHEMBL4878182 | — | — | 1 | 5.17 |
| CHEMBL4873561 | — | — | 1 | 4.72 |
| CHEMBL4847503 | — | — | 1 | 4.60 |
| CHEMBL4851869 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4855847 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4874191 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4876667 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4855868 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4879068 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4855407 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4854458 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4868343 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4872307 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4515740 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4849999 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4852349 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4862605 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4873606 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4849776 | — | EC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4875485 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4446467 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4848283 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4867027 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4873831 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4859732 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4866557 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4865656 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4862395 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4471300 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4867317 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4878182 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4873561 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4847503 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4851869 | — | EC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1071 | OXAPROZIN | EC50 | = | 40100.0 | nM | 4.40 |
| CHEMBL333698 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4847339 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4860614 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4864263 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4861965 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4846058 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4863720 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4874180 | — | EC50 | > | 30000.0 | nM | - |