Assay Detail
Functional
CHEMBL4836352
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Cytotoxicity against human A2780 cells assessed as reduction in cell viability incubated for 72 hrs in hypoxic condition by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A gemcitabine-based conjugate with enhanced antitumor efficacy by suppressing HIF-1α expression under hypoxia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.02 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869044 | — | — | 1 | 7.52 |
| CHEMBL1637 | GEMCITABINE HYDROCHLORIDE | 4.0 | 1 | 5.86 |
| CHEMBL333985 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869044 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1637 | GEMCITABINE HYDROCHLORIDE | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL333985 | — | IC50 | = | 20350.0 | nM | 4.69 |