Assay Detail
ADMET
CHEMBL4836813
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Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by addition of substrate and measured after 15 mins by Ellman's method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Equus caballus |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.72 | 4.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860689 | — | — | 1 | 4.84 |
| CHEMBL4852660 | — | — | 1 | 4.81 |
| CHEMBL4874834 | — | — | 1 | 4.79 |
| CHEMBL4870217 | — | — | 1 | 4.79 |
| CHEMBL4846102 | — | — | 1 | 4.74 |
| CHEMBL4849288 | — | — | 1 | 4.73 |
| CHEMBL4861468 | — | — | 1 | 4.70 |
| CHEMBL4875354 | — | — | 1 | 4.69 |
| CHEMBL4856085 | — | — | 1 | 4.69 |
| CHEMBL4871074 | — | — | 1 | 4.68 |
| CHEMBL4853059 | — | — | 1 | 4.68 |
| CHEMBL4876164 | — | — | 1 | 4.67 |
| CHEMBL4871454 | — | — | 1 | 4.67 |
| CHEMBL4879281 | — | — | 1 | 4.67 |
| CHEMBL456881 | DEOXYVASICINONE | — | 1 | 4.60 |
| CHEMBL497 | CLIOQUINOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860689 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4852660 | — | IC50 | = | 15380.0 | nM | 4.81 |
| CHEMBL4874834 | — | IC50 | = | 16050.0 | nM | 4.79 |
| CHEMBL4870217 | — | IC50 | = | 16180.0 | nM | 4.79 |
| CHEMBL4846102 | — | IC50 | = | 18190.0 | nM | 4.74 |
| CHEMBL4849288 | — | IC50 | = | 18470.0 | nM | 4.73 |
| CHEMBL4861468 | — | IC50 | = | 19860.0 | nM | 4.70 |
| CHEMBL4875354 | — | IC50 | = | 20520.0 | nM | 4.69 |
| CHEMBL4856085 | — | IC50 | = | 20420.0 | nM | 4.69 |
| CHEMBL4871074 | — | IC50 | = | 20920.0 | nM | 4.68 |
| CHEMBL4853059 | — | IC50 | = | 20820.0 | nM | 4.68 |
| CHEMBL4876164 | — | IC50 | = | 21650.0 | nM | 4.67 |
| CHEMBL4871454 | — | IC50 | = | 21490.0 | nM | 4.67 |
| CHEMBL4879281 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL456881 | DEOXYVASICINONE | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL497 | CLIOQUINOL | IC50 | - | — | - |