Assay Detail
Binding
CHEMBL4836861
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Inhibition of recombinant human full length His-tagged p110delta/p85alpha expressed in baculovirus expression system measured after 60 mins in presence of ATP by ATP-competitive binding assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 9.09 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4868117 | — | — | 1 | 10.05 |
| CHEMBL4852166 | — | — | 1 | 9.41 |
| CHEMBL4871071 | — | — | 1 | 9.40 |
| CHEMBL4845946 | — | — | 1 | 9.30 |
| CHEMBL4876309 | — | — | 1 | 9.30 |
| CHEMBL4853740 | — | — | 1 | 9.30 |
| CHEMBL4862467 | — | — | 1 | 9.22 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.97 |
| CHEMBL4874496 | — | — | 1 | 8.97 |
| CHEMBL4858100 | — | — | 1 | 8.97 |
| CHEMBL4874404 | — | — | 1 | 8.96 |
| CHEMBL4852863 | — | — | 1 | 8.89 |
| CHEMBL4876188 | — | — | 1 | 8.77 |
| CHEMBL4847494 | — | — | 1 | 8.74 |
| CHEMBL4870032 | — | — | 1 | 8.69 |
| CHEMBL4854194 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4868117 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL4852166 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL4871071 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4845946 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4876309 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4853740 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4862467 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL4874496 | — | IC50 | = | 1.08 | nM | 8.97 |
| CHEMBL4858100 | — | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL4874404 | — | IC50 | = | 1.09 | nM | 8.96 |
| CHEMBL4852863 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4876188 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4847494 | — | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL4870032 | — | IC50 | = | 2.05 | nM | 8.69 |
| CHEMBL4854194 | — | IC50 | = | 3.23 | nM | 8.49 |