Assay Detail
Binding
CHEMBL4839446
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NanoLuc-fused SLK (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
STE20-like serine/threonine-protein kinase (CHEMBL4202) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.39 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL156277 | — | — | 1 | 6.16 |
| CHEMBL4875188 | — | — | 1 | 5.92 |
| CHEMBL4878325 | — | — | 1 | 4.77 |
| CHEMBL4856751 | — | — | 1 | 4.72 |
| CHEMBL4877889 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL156277 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4875188 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4878325 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4856751 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4877889 | — | IC50 | > | 20000.0 | nM | - |