Assay Detail
Binding
CHEMBL4839494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CSF1R using ATP/Ulight-TK peptide incubated for 15 mins
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent Antiallergic Agents Based on an <i>o</i>-Aminopyridinyl Alkynyl Scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.17 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4576115 | — | — | 1 | 9.15 |
| CHEMBL4438121 | — | — | 1 | 8.89 |
| CHEMBL4517659 | — | — | 1 | 8.62 |
| CHEMBL4553298 | — | — | 1 | 8.59 |
| CHEMBL4589346 | — | — | 1 | 8.52 |
| CHEMBL4467948 | — | — | 1 | 8.23 |
| CHEMBL4854948 | — | — | 1 | 8.10 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 8.07 |
| CHEMBL3813873 | PEXIDARTINIB | 4.0 | 1 | 7.89 |
| CHEMBL4850154 | — | — | 1 | 7.66 |
| CHEMBL4854116 | — | — | 1 | 7.62 |
| CHEMBL4869362 | — | — | 1 | 7.52 |
| CHEMBL4862806 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4576115 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4438121 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4517659 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4553298 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4589346 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4467948 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4854948 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL3813873 | PEXIDARTINIB | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4850154 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4854116 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4869362 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4862806 | — | IC50 | = | 48.0 | nM | 7.32 |