Compound Detail
CHEMBL4517659
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4517659 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GVTLTEQOMHHSHA-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
475.5
MW (Da)
5.04
ALogP
5
HBA
2
HBD
85.8
PSA (Ų)
0.41
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 8.62 | 8.62 | 2.4 | 2 |
| RBL-2H3 CHEMBL614632 | IC50 | 8.56 | 8.56 | 2.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 2.4 | nM | 8.62 | Inhibition of recombinant CSF1R (unknown origin) using poly (Glu, Tyr)4:1 as sub... | 31934767 |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 2.4 | nM | 8.62 | Inhibition of human recombinant CSF1R using ATP/Ulight-TK peptide incubated for ... | 34476950 |
| RBL-2H3 | IC50 | = | 2.75 | nM | 8.56 | Antiallergic activity against anti-DNP-IgE sensitized rat RBL-2H3 cells assessed... | 34476950 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34476950 | 10.1021/acs.jmedchem.1c00976 | RBL-2H3 | 5 |
| 31934767 | 10.1021/acs.jmedchem.9b01912 | Macrophage colony-stimulating factor 1 receptor | 1 |
| 34476950 | 10.1021/acs.jmedchem.1c00976 | ADMET | 1 |
| 34476950 | 10.1021/acs.jmedchem.1c00976 | Macrophage colony-stimulating factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine