Assay Detail
Binding
CHEMBL4839698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarginine as a substrate preincubated for 30 mins followed by substrate addition and incubated for 60 mins by fluorescence based arginine thio ornithine generating assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.22 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850213 | — | — | 1 | 8.70 |
| CHEMBL4763578 | — | — | 1 | 8.52 |
| CHEMBL4778978 | — | — | 1 | 8.40 |
| CHEMBL4852406 | — | — | 1 | 8.30 |
| CHEMBL4864502 | — | — | 1 | 8.30 |
| CHEMBL4868283 | — | — | 1 | 8.15 |
| CHEMBL4872801 | — | — | 1 | 8.10 |
| CHEMBL4875641 | — | — | 1 | 7.96 |
| CHEMBL4858437 | — | — | 1 | 7.80 |
| CHEMBL4855923 | — | — | 1 | 7.72 |
| CHEMBL4863489 | — | — | 1 | 7.70 |
| CHEMBL4845882 | — | — | 1 | 7.54 |
| CHEMBL4862990 | — | — | 1 | 7.52 |
| CHEMBL4876150 | — | — | 1 | 7.48 |
| CHEMBL4856276 | — | — | 1 | 7.47 |
| CHEMBL4862982 | — | — | 1 | 7.34 |
| CHEMBL4868849 | — | — | 1 | 7.18 |
| CHEMBL4871410 | — | — | 1 | 7.16 |
| CHEMBL4855854 | — | — | 1 | 6.94 |
| CHEMBL4867493 | — | — | 1 | 6.92 |
| CHEMBL4853323 | — | — | 1 | 6.68 |
| CHEMBL4848931 | — | — | 1 | 6.61 |
| CHEMBL1812661 | — | — | 1 | 6.51 |
| CHEMBL4851360 | — | — | 1 | 6.47 |
| CHEMBL4870874 | — | — | 1 | 6.42 |
| CHEMBL4863179 | — | — | 1 | 6.38 |
| CHEMBL4856326 | — | — | 1 | 6.35 |
| CHEMBL4863141 | — | — | 1 | 6.18 |
| CHEMBL4875190 | — | — | 1 | 5.06 |
| CHEMBL4853009 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850213 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4763578 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4778978 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4852406 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4864502 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4868283 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4872801 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4875641 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4858437 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4855923 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4863489 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4845882 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4862990 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4876150 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4856276 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4862982 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4868849 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4871410 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4855854 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4867493 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4853323 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL4848931 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL1812661 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL4851360 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4870874 | — | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL4863179 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL4856326 | — | IC50 | = | 447.0 | nM | 6.35 |
| CHEMBL4863141 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4875190 | — | IC50 | = | 8733.0 | nM | 5.06 |
| CHEMBL4853009 | — | IC50 | = | 19840.0 | nM | 4.70 |
| CHEMBL4748950 | — | IC50 | < | 1.0 | nM | - |