Compound Detail
CHEMBL4862982
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Basic Information
| ChEMBL ID | CHEMBL4862982 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QBWYSKJNFZLVTC-CSMHCCOUSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
231.1
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.55
IC50 1 meas. best 7.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arginase-1 CHEMBL1075097 | IC50 | 7.34 | 7.34 | 46.0 | 1 |
| Arginase-1 CHEMBL1075097 | EC50 | 4.55 | 4.55 | 28000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arginase-1 | IC50 | = | 46.0 | nM | 7.34 | Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarg... | 34527178 |
| Arginase-1 | EC50 | = | 28000.0 | nM | 4.55 | Inhibition of human ARG1 in HEK293 cells by cell based assay | 34527178 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34527178 | 10.1021/acsmedchemlett.1c00195 | Arginase-1 | 2 |
Data from ChEMBL 36 via Core Engine