Assay Detail
Binding
CHEMBL4839701
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Inhibition of human ARG1 in HEK293 cells by cell based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.06 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4868283 | — | — | 1 | 5.55 |
| CHEMBL4858437 | — | — | 1 | 5.47 |
| CHEMBL4872801 | — | — | 1 | 5.38 |
| CHEMBL4876150 | — | — | 1 | 5.20 |
| CHEMBL4778978 | — | — | 1 | 5.16 |
| CHEMBL4855923 | — | — | 1 | 4.96 |
| CHEMBL4852406 | — | — | 1 | 4.85 |
| CHEMBL4862990 | — | — | 1 | 4.80 |
| CHEMBL4763578 | — | — | 1 | 4.70 |
| CHEMBL4862982 | — | — | 1 | 4.55 |
| CHEMBL4871410 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4868283 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4858437 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4872801 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4876150 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4778978 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4855923 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4852406 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4862990 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4763578 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4862982 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4871410 | — | EC50 | > | 30000.0 | nM | - |