Compound Detail
CHEMBL4858437
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4858437 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AMHQFAXDSRWEOU-RQJHMYQMSA-N |
1
Targets
3
Activities
2
Assay Types
2
PK Parameters
4
Publications
0
Known Names
Molecular Properties
201.0
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.8
EC50 1 meas. best 5.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arginase-1 CHEMBL1075097 | IC50 | 7.8 | 7.8 | 16.0 | 2 |
| Arginase-1 CHEMBL1075097 | EC50 | 5.47 | 5.47 | 3400.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 43.0 | % | Mus musculus |
| F | 25.0 | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arginase-1 | IC50 | = | 16.0 | nM | 7.8 | Inhibition of human recombinant ARG1 expressed in Escherichia coli using thioarg... | 34527178 |
| Arginase-1 | IC50 | = | 16.0 | nM | 7.8 | Inhibition of ARG1 (unknown origin) assessed as reduction in thio-ornithine prod... | 34795856 |
| Arginase-1 | EC50 | = | 3400.0 | nM | 5.47 | Inhibition of human ARG1 in HEK293 cells by cell based assay | 34527178 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34527178 | 10.1021/acsmedchemlett.1c00195 | ADMET | 6 |
| 34527178 | 10.1021/acsmedchemlett.1c00195 | Unchecked | 6 |
| 34527178 | 10.1021/acsmedchemlett.1c00195 | Arginase-1 | 2 |
| 34795856 | 10.1021/acsmedchemlett.1c00258 | Arginase-1 | 1 |
Data from ChEMBL 36 via Core Engine