Assay Detail
Functional
CHEMBL4841967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.97 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364637 | TENOFOVIR ALAFENAMIDE FUMARATE | 4.0 | 1 | 8.30 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 7.30 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364637 | TENOFOVIR ALAFENAMIDE FUMARATE | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 5000.0 | nM | 5.30 |