Assay Detail
Functional
CHEMBL4843119
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Antiviral activity against Zika virus H/PF/2013 infected in pre-seeded Huh-7 cells assessed as inhibition of viral replication incubated for 72 hrs by immunodetection based direct yield reduction assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Zika virus |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.70 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848338 | — | — | 1 | 6.10 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 5.57 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848338 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1259059 | SOFOSBUVIR | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1643 | RIBAVIRIN | IC50 | = | 3800.0 | nM | 5.42 |