Assay Detail
ADMET
CHEMBL4843243
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Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins in presence of NADPH by LCMS/MS analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.31 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852532 | — | — | 1 | 5.96 |
| CHEMBL4866113 | — | — | 1 | 5.89 |
| CHEMBL4846874 | — | — | 1 | 5.85 |
| CHEMBL4872803 | — | — | 1 | 5.72 |
| CHEMBL4852881 | — | — | 1 | 5.68 |
| CHEMBL4872522 | — | — | 1 | 5.48 |
| CHEMBL4868112 | — | — | 1 | 5.27 |
| CHEMBL4873928 | — | — | 1 | 5.17 |
| CHEMBL4873892 | — | — | 1 | 4.89 |
| CHEMBL4870664 | — | — | 1 | 4.75 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 4.55 |
| CHEMBL4848055 | — | — | 1 | 4.51 |
| CHEMBL4875089 | — | — | 1 | - |
| CHEMBL4853036 | — | — | 1 | - |
| CHEMBL4854742 | — | — | 1 | - |
| CHEMBL4848111 | — | — | 1 | - |
| CHEMBL4865079 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852532 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4866113 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4846874 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4872803 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4852881 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4872522 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4868112 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4873928 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4873892 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4870664 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4848055 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL4875089 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4853036 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL4854742 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4848111 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL4865079 | — | IC50 | > | 50000.0 | nM | - |