Assay Detail
ADMET
CHEMBL4843280
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Inhibition of CYP2C9 in human liver microsomes using sulfaphenazole as substrate incubated for 10 mins in presence of NADPH by LCMS/MS analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.45 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4878988 | — | — | 1 | 6.75 |
| CHEMBL4849690 | — | — | 1 | 6.04 |
| CHEMBL4855340 | — | — | 1 | 5.85 |
| CHEMBL4852566 | — | — | 1 | 5.80 |
| CHEMBL4861332 | — | — | 1 | 5.75 |
| CHEMBL4856417 | — | — | 1 | 5.72 |
| CHEMBL4858888 | — | — | 1 | 5.72 |
| CHEMBL4866916 | — | — | 1 | 5.68 |
| CHEMBL4862584 | — | — | 1 | 5.68 |
| CHEMBL4858219 | — | — | 1 | 5.66 |
| CHEMBL4861936 | — | — | 1 | 5.57 |
| CHEMBL4872039 | — | — | 1 | 5.51 |
| CHEMBL4873803 | — | — | 1 | 5.41 |
| CHEMBL4866976 | — | — | 1 | 5.38 |
| CHEMBL4873747 | — | — | 1 | 5.37 |
| CHEMBL4870583 | — | — | 1 | 5.34 |
| CHEMBL4877654 | — | — | 1 | 5.29 |
| CHEMBL4856710 | — | — | 1 | 5.21 |
| CHEMBL4862755 | — | — | 1 | 5.21 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 5.11 |
| CHEMBL4878766 | — | — | 1 | 5.11 |
| CHEMBL4857514 | — | — | 1 | 5.10 |
| CHEMBL4865106 | — | — | 1 | 4.80 |
| CHEMBL4870435 | — | — | 1 | 4.64 |
| CHEMBL4853212 | — | — | 1 | 4.64 |
| CHEMBL4853456 | — | — | 1 | - |
| CHEMBL4879173 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4878988 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4849690 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4855340 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4852566 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4861332 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4856417 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4858888 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4866916 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4862584 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4858219 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4861936 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4872039 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4873803 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4866976 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4873747 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4870583 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4877654 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4856710 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4862755 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4878766 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4857514 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4865106 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4870435 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4853212 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4853456 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4879173 | — | IC50 | > | 30000.0 | nM | - |