Assay Detail
Binding
CHEMBL4844236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP assessed as reduction in ADPR-induced current by whole cell patch-clamp method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 2 (CHEMBL1250402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological activities of benzo[d]imidazo[1,2-a]imidazole derivatives as TRPM2-specfic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.20 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169233 | — | — | 1 | 5.30 |
| CHEMBL4872096 | — | — | 1 | 5.21 |
| CHEMBL4873412 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169233 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4872096 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4873412 | — | IC50 | = | 8100.0 | nM | 5.09 |