Compound Detail
CHEMBL4873412
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Basic Information
| ChEMBL ID | CHEMBL4873412 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UQYHWOPWRVCWLU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
414.5
MW (Da)
4.92
ALogP
6
HBA
0
HBD
55.7
PSA (Ų)
0.35
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 2 CHEMBL1250402 | IC50 | 5.09 | 5.09 | 8100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily M member 2 | IC50 | = | 8100.0 | nM | 5.09 | Inhibition of human TRPM2 expressed in HEK293T cells cotransfected with GFP asse... | 34416664 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34416664 | 10.1016/j.ejmech.2021.113750 | SH-SY5Y | 5 |
| 34416664 | 10.1016/j.ejmech.2021.113750 | Transient receptor potential cation channel subfamily M member 2 | 3 |
| 34416664 | 10.1016/j.ejmech.2021.113750 | Transient receptor potential cation channel subfamily M member 8 | 1 |
| 34416664 | 10.1016/j.ejmech.2021.113750 | Transient receptor potential cation channel subfamily V member 1 | 1 |
| 34416664 | 10.1016/j.ejmech.2021.113750 | Unchecked | 1 |
| 34416664 | 10.1016/j.ejmech.2021.113750 | Calcium release-activated calcium channel protein 1 | 1 |
Data from ChEMBL 36 via Core Engine