Assay Detail
Functional
CHEMBL4845278
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Antiproliferative activity against human THP-1 cells incubated for 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.51 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.60 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.52 |
| CHEMBL4878408 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 2.49 | nM | 8.60 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.01 | nM | 8.52 |
| CHEMBL4878408 | — | IC50 | = | 3.83 | nM | 8.42 |