Assay Detail
ADMET
CHEMBL4845510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP2D6 expressed in insect cells using AMMC as substrate preincubated for 30 mins followed by NADPH regenerating system addition and measured after 45 mins by fluorescence based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amino-Heterocycle Tetrahydroisoquinoline CXCR4 Antagonists with Improved ADME Profiles via Late-Stage Buchwald Couplings.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.32 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3091687 | — | — | 1 | 6.50 |
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | 5.79 |
| CHEMBL4877757 | — | — | 1 | 5.43 |
| CHEMBL4846946 | — | — | 1 | 5.40 |
| CHEMBL4853570 | — | — | 1 | 5.11 |
| CHEMBL4863276 | — | — | 1 | 4.81 |
| CHEMBL4862362 | — | — | 1 | 4.76 |
| CHEMBL4875030 | — | — | 1 | 4.73 |
| CHEMBL4849088 | — | — | 1 | - |
| CHEMBL4864332 | — | — | 1 | - |
| CHEMBL4857452 | — | — | 1 | - |
| CHEMBL4876951 | — | — | 1 | - |
| CHEMBL4858136 | — | — | 1 | - |
| CHEMBL4862509 | — | — | 1 | - |
| CHEMBL4874526 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3091687 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL518924 | MAVORIXAFOR | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4877757 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL4846946 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL4853570 | — | IC50 | = | 7810.0 | nM | 5.11 |
| CHEMBL4863276 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4862362 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL4875030 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL4849088 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4864332 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4857452 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4876951 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4858136 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4862509 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4874526 | — | IC50 | > | 20000.0 | nM | - |