Assay Detail
Binding
CHEMBL4883056
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Biochemical assay (PDE4A)
2
Total Activities
2
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Data for DCP probe THPP-1
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 5.12 | 5.23 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | IMAP phosphodiesterase assay (Molecular devices) |
| Assay publication | Assay publication | - | — | PMID: 22892116 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2204538 | THPP-1 | — | 1 | 5.23 |
| CHEMBL4518342 | THPP-1-NC | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2204538 | THPP-1 | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL4518342 | THPP-1-NC | Ki | = | 9830.0 | nM | 5.01 |