Assay Detail
Binding
CHEMBL4883789
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NanoBRET (MAPK14)
5
Total Activities
5
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe FS-694
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.79 | 8.43 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Target protein length | Target protein length | - | — | full length |
| Target protein type | Target protein type | - | — | HEK cells |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436748 | SR-318 | — | 1 | 8.43 |
| CHEMBL2152944 | Skepinone-L | — | 1 | 7.87 |
| CHEMBL2316207 | FS-694 | — | 1 | 7.83 |
| CHEMBL4586225 | FM-743 | — | 1 | 4.95 |
| CHEMBL4531775 | SR-321 | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436748 | SR-318 | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2152944 | Skepinone-L | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL2316207 | FS-694 | IC50 | = | 14.9 | nM | 7.83 |
| CHEMBL4586225 | FM-743 | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4531775 | SR-321 | IC50 | = | 13000.0 | nM | 4.89 |