Compound Detail
CHEMBL4586225
FM-743 Enter ChEMBL ID:
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CN(C(=O)c1ccccc1)c1cc(N(C)c2ccc3c(c2)CCc2ccc(C(=O)NCCN4CCOCC4)cc2C3=O)ccc1F
Basic Information
| ChEMBL ID | CHEMBL4586225 |
| Name | FM-743 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RHXKLUBQGQKHCH-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
620.7
MW (Da)
5.26
ALogP
6
HBA
1
HBD
82.2
PSA (Ų)
0.29
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 4.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 4.95 | 4.95 | 11300.0 | 2 |
| Mitogen-activated protein kinase 11 CHEMBL3961 | IC50 | 4.79 | 4.79 | 16200.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 11300.0 | nM | 4.95 | NanoBRET (MAPK14) | - |
| Mitogen-activated protein kinase 14 | IC50 | = | 11300.0 | nM | 4.95 | Affinity On-target Cellular interaction: (NanoBRET assay (HEK293T cells)) EUB000... | - |
| Mitogen-activated protein kinase 11 | IC50 | = | 16200.0 | nM | 4.79 | NanoBRET (MAPK11) | - |
| Mitogen-activated protein kinase 11 | IC50 | = | 16200.0 | nM | 4.79 | Affinity On-target Cellular interaction: (NanoBRET assay (HEK293T cells)) EUB000... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5058564 | Fibroblast | 10 |
| - | 10.6019/CHEMBL5058564 | U2OS | 8 |
| - | 10.6019/CHEMBL5058564 | HEK-293T | 8 |
| - | 10.6019/CHEMBL5608141 | Colon cancer organoid | 6 |
| - | 10.1158/2159-8290.CD-23-0050 | Colon cancer organoid | 5 |
| - | 10.6019/CHEMBL5060014 | Casein kinase I isoform delta | 1 |
| - | 10.6019/CHEMBL5465560 | Serine/threonine-protein kinase Nek1 | 1 |
| - | 10.6019/CHEMBL5445981 | Mitogen-activated protein kinase 14 | 1 |
| - | 10.6019/CHEMBL5060014 | Transcription intermediary factor 1-alpha | 1 |
| - | 10.6019/CHEMBL5060014 | Mitogen-activated protein kinase 1 | 1 |
| - | 10.6019/CHEMBL5060014 | Glycogen synthase kinase-3 beta | 1 |
| - | 10.6019/CHEMBL5060014 | Fibroblast growth factor receptor 3 | 1 |
| - | 10.6019/CHEMBL4507314 | Mitogen-activated protein kinase 14 | 1 |
| - | 10.1021/acschembio.2c00877 | Colon organoid | 1 |
| - | 10.6019/CHEMBL5060014 | Peregrin | 1 |
| - | 10.6019/CHEMBL5060014 | Bromodomain-containing protein 4 | 1 |
| - | 10.6019/CHEMBL5060014 | Aurora kinase A | 1 |
| - | 10.6019/CHEMBL5060014 | Tyrosine-protein kinase ABL1 | 1 |
Data from ChEMBL 36 via Core Engine