Assay Detail
Binding
CHEMBL5030192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPDPE from DOR in Wistar rat brain membranes measured after 3 hrs by scintillation counting method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Cyclic Endomorphin Analogues with Multiple Modifications and Oligoarginine Vector Exhibit Potent Antinociception with Reduced Opioid-like Side Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.33 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076581 | — | — | 1 | 5.68 |
| CHEMBL5085104 | — | — | 1 | 5.37 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 5.21 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 5.06 |
| CHEMBL5080666 | — | — | 1 | - |
| CHEMBL5084034 | — | — | 1 | - |
| CHEMBL5080233 | — | — | 1 | - |
| CHEMBL5078349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076581 | — | Ki | = | 2087.0 | nM | 5.68 |
| CHEMBL5085104 | — | Ki | = | 4274.0 | nM | 5.37 |
| CHEMBL316446 | ENDOMORPHIN-1 | Ki | = | 6105.0 | nM | 5.21 |
| CHEMBL333357 | ENDOMORPHIN 2 | Ki | = | 8770.0 | nM | 5.06 |
| CHEMBL5080666 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5084034 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5080233 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL5078349 | — | Ki | > | 10000.0 | nM | - |