Assay Detail
Binding
CHEMBL5033142
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Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents <i>In Vitro</i> and <i>In Vivo</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.09 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 7.16 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.10 |
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | 6.68 |
| CHEMBL5077595 | — | — | 1 | 6.52 |
| CHEMBL5089355 | — | — | 1 | 6.47 |
| CHEMBL5075246 | — | — | 1 | 6.00 |
| CHEMBL316040 | TEPOXALIN | 2.0 | 1 | 5.54 |
| CHEMBL5083953 | — | — | 1 | 4.89 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.82 |
| CHEMBL5085564 | — | — | 1 | 4.28 |
| CHEMBL5089124 | — | — | 1 | 4.27 |
| CHEMBL5080730 | — | — | 1 | 4.26 |
| CHEMBL5079967 | — | — | 1 | 4.22 |
| CHEMBL5075058 | — | — | 1 | 4.16 |
| CHEMBL5084005 | — | — | 1 | 4.10 |
| CHEMBL5090304 | — | — | 1 | 4.07 |
| CHEMBL5080948 | — | — | 1 | 4.05 |
| CHEMBL5085191 | — | — | 1 | 4.05 |
| CHEMBL5091817 | — | — | 1 | 4.02 |
| CHEMBL5085345 | — | — | 1 | - |
| CHEMBL5081272 | — | — | 1 | - |
| CHEMBL5094855 | — | — | 1 | - |
| CHEMBL5084816 | — | — | 1 | - |
| CHEMBL5075348 | — | — | 1 | - |
| CHEMBL5082428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL300982 | LICOFELONE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5077595 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5089355 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5075246 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL316040 | TEPOXALIN | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL5083953 | — | IC50 | = | 12870.0 | nM | 4.89 |
| CHEMBL118 | CELECOXIB | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5085564 | — | IC50 | = | 53080.0 | nM | 4.28 |
| CHEMBL5089124 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL5080730 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL5079967 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL5075058 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL5084005 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL5090304 | — | IC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL5080948 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL5085191 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL5091817 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL5085345 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5081272 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL5094855 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL5084816 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5075348 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5082428 | — | IC50 | > | 10000.0 | nM | - |