Assay Detail
Functional
CHEMBL5033902
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A2780 cells assessed as inhibition of cell proliferation measured after 120 hrs by Cell-titre glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.89 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475351 | — | — | 1 | 6.33 |
| CHEMBL5090239 | — | — | 1 | 6.17 |
| CHEMBL5082755 | — | — | 1 | 6.01 |
| CHEMBL4524352 | — | — | 1 | 5.57 |
| CHEMBL5083020 | — | — | 1 | 5.35 |
| CHEMBL4282264 | A-485 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475351 | — | EC50 | = | 471.0 | nM | 6.33 |
| CHEMBL5090239 | — | EC50 | = | 678.0 | nM | 6.17 |
| CHEMBL5082755 | — | EC50 | = | 974.0 | nM | 6.01 |
| CHEMBL4524352 | — | EC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL5083020 | — | EC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL4282264 | A-485 | EC50 | - | — | - |