Assay Detail
Functional
CHEMBL5034973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human melanocortin receptor 3 expressed in human T-REx-293 cells assessed as stimulation of intracellular cAMP accumulation incubated for 45 mins by LANCE cAMP assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-REx-293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 8.01 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | — | 1 | 10.21 |
| CHEMBL3301624 | SETMELANOTIDE | 4.0 | 1 | 9.82 |
| CHEMBL2070241 | BREMELANOTIDE | 4.0 | 1 | 9.17 |
| CHEMBL5090946 | — | — | 1 | 8.94 |
| CHEMBL5087859 | — | — | 1 | 8.91 |
| CHEMBL5083551 | — | — | 1 | 8.84 |
| CHEMBL5087839 | — | — | 1 | 8.66 |
| CHEMBL5094168 | — | — | 1 | 8.45 |
| CHEMBL5080489 | — | — | 1 | 8.39 |
| CHEMBL5090285 | — | — | 1 | 8.18 |
| CHEMBL5080784 | — | — | 1 | 8.18 |
| CHEMBL5077095 | — | — | 1 | 8.11 |
| CHEMBL5091236 | — | — | 1 | 7.95 |
| CHEMBL5076315 | — | — | 1 | 7.87 |
| CHEMBL5087814 | — | — | 1 | 7.80 |
| CHEMBL5077144 | — | — | 1 | 7.79 |
| CHEMBL5075712 | — | — | 1 | 7.76 |
| CHEMBL5092761 | — | — | 1 | 7.74 |
| CHEMBL5090670 | — | — | 1 | 7.70 |
| CHEMBL5081077 | — | — | 1 | 7.62 |
| CHEMBL5094215 | — | — | 1 | 7.41 |
| CHEMBL5085972 | — | — | 1 | 7.40 |
| CHEMBL5078687 | — | — | 1 | 7.25 |
| CHEMBL5075506 | — | — | 1 | 7.14 |
| CHEMBL5091245 | — | — | 1 | 7.02 |
| CHEMBL5093939 | — | — | 1 | 6.89 |
| CHEMBL4099889 | — | — | 1 | 6.55 |
| CHEMBL5077811 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430239 | MELATONAN | EC50 | = | 0.06166 | nM | 10.21 |
| CHEMBL3301624 | SETMELANOTIDE | EC50 | = | 0.1514 | nM | 9.82 |
| CHEMBL2070241 | BREMELANOTIDE | EC50 | = | 0.6761 | nM | 9.17 |
| CHEMBL5090946 | — | EC50 | = | 1.148 | nM | 8.94 |
| CHEMBL5087859 | — | EC50 | = | 1.23 | nM | 8.91 |
| CHEMBL5083551 | — | EC50 | = | 1.445 | nM | 8.84 |
| CHEMBL5087839 | — | EC50 | = | 2.188 | nM | 8.66 |
| CHEMBL5094168 | — | EC50 | = | 3.548 | nM | 8.45 |
| CHEMBL5080489 | — | EC50 | = | 4.074 | nM | 8.39 |
| CHEMBL5090285 | — | EC50 | = | 6.607 | nM | 8.18 |
| CHEMBL5080784 | — | EC50 | = | 6.607 | nM | 8.18 |
| CHEMBL5077095 | — | EC50 | = | 7.762 | nM | 8.11 |
| CHEMBL5091236 | — | EC50 | = | 11.22 | nM | 7.95 |
| CHEMBL5076315 | — | EC50 | = | 13.49 | nM | 7.87 |
| CHEMBL5087814 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL5077144 | — | EC50 | = | 16.22 | nM | 7.79 |
| CHEMBL5075712 | — | EC50 | = | 17.38 | nM | 7.76 |
| CHEMBL5092761 | — | EC50 | = | 18.2 | nM | 7.74 |
| CHEMBL5090670 | — | EC50 | = | 19.95 | nM | 7.70 |
| CHEMBL5081077 | — | EC50 | = | 23.99 | nM | 7.62 |
| CHEMBL5094215 | — | EC50 | = | 38.9 | nM | 7.41 |
| CHEMBL5085972 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL5078687 | — | EC50 | = | 56.23 | nM | 7.25 |
| CHEMBL5075506 | — | EC50 | = | 72.44 | nM | 7.14 |
| CHEMBL5091245 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL5093939 | — | EC50 | = | 128.82 | nM | 6.89 |
| CHEMBL4099889 | — | EC50 | = | 281.84 | nM | 6.55 |
| CHEMBL5077811 | — | EC50 | = | 398.11 | nM | 6.40 |