Assay Detail
Binding
CHEMBL5035180
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Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-ATP
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.92 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5080010 | — | — | 1 | 8.62 |
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 8.60 |
| CHEMBL5093999 | — | — | 1 | 8.49 |
| CHEMBL5070835 | — | — | 1 | 8.31 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | 8.17 |
| CHEMBL5091992 | — | — | 1 | 7.17 |
| CHEMBL5085914 | — | — | 1 | 6.07 |
| CHEMBL5092304 | — | — | 1 | - |
| CHEMBL5085584 | — | — | 1 | - |
| CHEMBL5082188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5080010 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5093999 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5070835 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL5091992 | — | IC50 | = | 67.5 | nM | 7.17 |
| CHEMBL5085914 | — | IC50 | = | 846.0 | nM | 6.07 |
| CHEMBL5092304 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5085584 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5082188 | — | IC50 | > | 1000.0 | nM | - |