Compound Detail
CHEMBL5091992
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Basic Information
| ChEMBL ID | CHEMBL5091992 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GWBVBLVGPBGBPS-BMTQXLHTSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
394.4
MW (Da)
1.90
ALogP
7
HBA
1
HBD
84.7
PSA (Ų)
0.63
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 7.17 | 7.17 | 67.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 67.5 | nM | 7.17 | Inhibition of TrKA (unknown origin) incubated for 120 mins in presence of 33P-AT... | 34253025 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34253025 | 10.1021/acs.jmedchem.1c00712 | High affinity nerve growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine