Assay Detail
ADMET
CHEMBL5035200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C9 in human pooled liver microsomes using diclofenac as substrate in presence of NADPH by LC-MS/MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Next-Generation Pan-TRK Kinase Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.97 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | 4.0 | 1 | 5.19 |
| CHEMBL5080010 | — | — | 1 | 4.74 |
| CHEMBL4297627 | SELITRECTINIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298138 | REPOTRECTINIB | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5080010 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4297627 | SELITRECTINIB | IC50 | > | 50000.0 | nM | - |