Assay Detail
Functional
CHEMBL5036388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 infected in human MRC-5 cells assessed as parasite growth
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.09 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5073339 | — | — | 1 | 7.28 |
| CHEMBL4094088 | — | — | 1 | 7.21 |
| CHEMBL4066553 | — | — | 1 | 6.85 |
| CHEMBL5085151 | — | — | 1 | 6.82 |
| CHEMBL4740928 | — | — | 1 | 6.75 |
| CHEMBL5087418 | — | — | 1 | 6.60 |
| CHEMBL5089586 | — | — | 1 | 6.54 |
| CHEMBL5076358 | — | — | 1 | 6.54 |
| CHEMBL5077758 | — | — | 1 | 6.47 |
| CHEMBL5078991 | — | — | 1 | 6.47 |
| CHEMBL5091586 | — | — | 1 | 6.36 |
| CHEMBL4777742 | — | — | 1 | 6.35 |
| CHEMBL5076866 | — | — | 1 | 6.28 |
| CHEMBL5094515 | — | — | 1 | 6.23 |
| CHEMBL5077047 | — | — | 1 | 6.20 |
| CHEMBL5089485 | — | — | 1 | 6.14 |
| CHEMBL5077619 | — | — | 1 | 6.11 |
| CHEMBL5083939 | — | — | 1 | 6.07 |
| CHEMBL5077670 | — | — | 1 | 6.05 |
| CHEMBL5071689 | — | — | 1 | 6.03 |
| CHEMBL5092257 | — | — | 1 | 6.03 |
| CHEMBL5072498 | — | — | 1 | 6.03 |
| CHEMBL5093590 | — | — | 1 | 6.01 |
| CHEMBL5090806 | — | — | 1 | 6.00 |
| CHEMBL5080663 | — | — | 1 | 6.00 |
| CHEMBL5092163 | — | — | 1 | 5.96 |
| CHEMBL5081962 | — | — | 1 | 5.75 |
| CHEMBL5084334 | — | — | 1 | 5.51 |
| CHEMBL5091037 | — | — | 1 | 5.48 |
| CHEMBL5078497 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5073339 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4094088 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4066553 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5085151 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4740928 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5087418 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5089586 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5076358 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5077758 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5078991 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5091586 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4777742 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5076866 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5094515 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5077047 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5089485 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5077619 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5083939 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5077670 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5071689 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5092257 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5072498 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5093590 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5090806 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5080663 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5092163 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5081962 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5084334 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5091037 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5078497 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5092648 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5076480 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5078924 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5076723 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5072526 | — | IC50 | = | 39000.0 | nM | 4.41 |