Assay Detail
Functional
CHEMBL5037438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A2780 cells assessed as inhibition of cell growth in presence of fetal calf serum incubated for 96 hrs measured by celltiter-glo luminescent cell viability assay
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.95 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3973367 | — | — | 1 | 7.43 |
| CHEMBL5087022 | — | — | 1 | 7.35 |
| CHEMBL5074835 | — | — | 1 | 7.34 |
| CHEMBL4589249 | — | — | 1 | 7.28 |
| CHEMBL3962241 | — | — | 2 | 7.24 |
| CHEMBL3960677 | — | — | 1 | 7.23 |
| CHEMBL5075021 | — | — | 1 | 6.90 |
| CHEMBL3897217 | — | — | 1 | 6.84 |
| CHEMBL4793497 | — | — | 1 | 6.74 |
| CHEMBL5083608 | — | — | 1 | 6.65 |
| CHEMBL5092100 | — | — | 1 | 6.58 |
| CHEMBL4286578 | — | — | 1 | 6.42 |
| CHEMBL5075605 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3973367 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5087022 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5074835 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4589249 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3962241 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3960677 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL3962241 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5075021 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL3897217 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4793497 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL5083608 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL5092100 | — | IC50 | = | 262.0 | nM | 6.58 |
| CHEMBL4286578 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5075605 | — | IC50 | = | 692.0 | nM | 6.16 |