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Assay Detail

CHEMBL5041281

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Angiogenic activity in mouse C2C12 cells assessed as reversal of hyperglycemia-induced reduction in cell number by measuring cell proliferation measured after 12 to 36 hrs
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type C2C12
Confidence 1 — Organism
Curated By Autocuration

Target

C2C12 (CHEMBL612655)
Type CELL-LINE
Organism Mus musculus

Publication

Discovery of Salidroside-Derivated Glycoside Analogues as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia.
Liu C, Han J, Marcelina O, Nugrahaningrum DA, Huang S, Zou M, Wang G, Miyagishi M, He Y, Wu S, Kasim V.
J Med Chem (2022) 65 : 135 -162
PubMed 34939794 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 4.76 4.76

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5074637 1 4.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5074637 EC50 = 17320.0 nM 4.76