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Target Snapshot

CHEMBL612655 Target Snapshot

C2C12 · CELL-LINE · Mus musculus

522Compounds
294Assays
0Approved Drugs
65.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C2C12 as ChEMBL target CHEMBL612655. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C2C12
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL612655
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C2C12 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC2C12
UniProt AccessionN/A

C2C12

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as C2C12.

Review nameC2C12
OrganismMus musculus
Assay Mix

Activity Type Distribution

IC5054.0
EC5011.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2017441 8.1 IC50 8.0 Preclinical
CHEMBL3343188 6.52 IC50 300.0 Preclinical
CHEMBL1224891 5.83 EC50 1470.0 Preclinical
CHEMBL3343191 5.19 IC50 6500.0 Preclinical
CHEMBL3343189 5.12 IC50 7500.0 Preclinical
CHEMBL5074637 4.9 EC50 12700.0 Preclinical
CHEMBL2071308 4.86 EC50 13800.0 Preclinical
CHEMBL234316 4.73 EC50 18500.0 Preclinical
CHEMBL2071307 4.59 EC50 25900.0 Preclinical
CHEMBL2071309 4.59 EC50 25600.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
1
5.5
1
6.0
1
6.5
0
7.0
0
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

294
Total Assays
10
Tested Compounds
3
Assay Types
Functional — 220 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 220 10 5.1
ADME — 63 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 63 0
Toxicity — 11 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 1 8.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine