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Compound Detail

CHEMBL2071309

GOODYEROSIDE
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O=C1C[C@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)CO1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2071309
Name GOODYEROSIDE
Phase Preclinical
Structure Type MOL
InChI Key MQEPWBMWFIVRPS-MBOSOLAWSA-N
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

264.2
MW (Da)
-2.88
ALogP
8
HBA
4
HBD
125.7
PSA (Ų)
0.40
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C10H16O8
MW 264.23
Aromatic Rings 0
Heavy Atoms 18
NP-Likeness 2.62

Activity Summary

IC50 2 meas. best 4.55
EC50 1 meas. best 4.59

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
C2C12
CHEMBL612655
 EC50 4.59 4.59 25600.0 1
RAW264.7
CHEMBL612557
 IC50 4.55 4.55 27870.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
C2C12 EC50 = 25600.0 nM 4.59 Increase in glucose uptake in mouse C2C12 cells incubated for 18 hrs using [3H]-... 22738356
RAW264.7 IC50 = 27870.0 nM 4.55 Antiinflammatory activity against mouse RAW 264.7 cells assessed as inhibition o... 33223464

Literature References

PubMed DOI Target Context # Activities
33223464 10.1016/j.bmc.2020.115854 RAW264.7 11
22738356 10.1021/np3001317 C2C12 2
22738356 10.1021/np3001317 Glucose-6-phosphatase catalytic subunit 1 2

Data from ChEMBL 36 via Core Engine