Assay Detail
ADMET
CHEMBL5041739
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP3A4 by fluorescence plate reader analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.52 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5075933 | — | — | 1 | 6.05 |
| CHEMBL5073381 | — | — | 1 | 5.51 |
| CHEMBL5088449 | — | — | 1 | 5.36 |
| CHEMBL2152899 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5075933 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5073381 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL5088449 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2152899 | — | IC50 | = | 6700.0 | nM | 5.17 |