Assay Detail
Binding
CHEMBL5042870
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Displacement of [125I]-Kp-10 from human Kiss1 receptor by TopCount scintillation counting method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of an <i>N</i>-acylated-<sup>D</sup>Arg-Leu-NH<sub>2</sub> Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 10.21 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376756 | KISSPEPTIN-10 | 3.0 | 1 | 10.21 |
| CHEMBL5074999 | — | — | 1 | - |
| CHEMBL5091013 | — | — | 1 | - |
| CHEMBL5085324 | — | — | 1 | - |
| CHEMBL4776204 | — | — | 1 | - |
| CHEMBL5082678 | — | — | 1 | - |
| CHEMBL1802414 | — | — | 1 | - |
| CHEMBL38874 | DAMGO | — | 1 | - |
| CHEMBL31421 | — | — | 1 | - |
| CHEMBL80 | NALOXONE | 4.0 | 1 | - |
| CHEMBL396460 | NOCICEPTIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376756 | KISSPEPTIN-10 | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL5074999 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL5091013 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL5085324 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4776204 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL5082678 | — | Ki | - | — | - | |
| CHEMBL1802414 | — | Ki | - | — | - | |
| CHEMBL38874 | DAMGO | Ki | - | — | - | |
| CHEMBL31421 | — | Ki | - | — | - | |
| CHEMBL80 | NALOXONE | Ki | - | — | - | |
| CHEMBL396460 | NOCICEPTIN | Ki | - | — | - |