Assay Detail
Functional
CHEMBL5043376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu opioid receptor (unknown origin) assessed as increase in cAMP level incubated for 40 mins by spectrophotometry
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 8.27 | 10.15 |
| Emax | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5074742 | — | — | 1 | 10.15 |
| CHEMBL5082714 | — | — | 1 | 10.00 |
| CHEMBL5084800 | — | — | 1 | 9.70 |
| CHEMBL5083403 | — | — | 1 | 9.46 |
| CHEMBL5075300 | — | — | 1 | 9.34 |
| CHEMBL5082522 | — | — | 1 | 9.30 |
| CHEMBL2443262 | OLICERIDINE | 4.0 | 1 | 8.74 |
| CHEMBL5078909 | — | — | 1 | 8.74 |
| CHEMBL38874 | DAMGO | — | 1 | 8.71 |
| CHEMBL5077763 | — | — | 1 | 8.70 |
| CHEMBL5093645 | — | — | 1 | 8.59 |
| CHEMBL5093937 | — | — | 1 | 8.39 |
| CHEMBL5088860 | — | — | 1 | 8.21 |
| CHEMBL5087703 | — | — | 1 | 8.17 |
| CHEMBL4467777 | — | — | 1 | 8.00 |
| CHEMBL5079835 | — | — | 1 | 7.94 |
| CHEMBL5084268 | — | — | 1 | 7.89 |
| CHEMBL5079983 | — | — | 1 | 7.85 |
| CHEMBL5085321 | — | — | 1 | 7.70 |
| CHEMBL5080554 | — | — | 1 | 7.70 |
| CHEMBL5083135 | — | — | 1 | 7.65 |
| CHEMBL5069961 | — | — | 1 | 7.58 |
| CHEMBL5091110 | — | — | 1 | 7.21 |
| CHEMBL5092009 | — | — | 1 | 6.76 |
| CHEMBL5077091 | — | — | 1 | 6.75 |
| CHEMBL5090537 | — | — | 1 | 5.71 |
| CHEMBL5088559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5074742 | — | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL5082714 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5084800 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5083403 | — | EC50 | = | 0.35 | nM | 9.46 |
| CHEMBL5075300 | — | EC50 | = | 0.46 | nM | 9.34 |
| CHEMBL5082522 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2443262 | OLICERIDINE | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5078909 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL38874 | DAMGO | EC50 | = | 1.97 | nM | 8.71 |
| CHEMBL5077763 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5093645 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL5093937 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL5088860 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5087703 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4467777 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5079835 | — | EC50 | = | 11.6 | nM | 7.94 |
| CHEMBL5084268 | — | EC50 | = | 12.8 | nM | 7.89 |
| CHEMBL5079983 | — | EC50 | = | 14.1 | nM | 7.85 |
| CHEMBL5085321 | — | EC50 | = | 19.9 | nM | 7.70 |
| CHEMBL5080554 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5083135 | — | EC50 | = | 22.3 | nM | 7.65 |
| CHEMBL5069961 | — | EC50 | = | 26.5 | nM | 7.58 |
| CHEMBL5091110 | — | EC50 | = | 61.6 | nM | 7.21 |
| CHEMBL5092009 | — | EC50 | = | 174.2 | nM | 6.76 |
| CHEMBL5077091 | — | EC50 | = | 178.0 | nM | 6.75 |
| CHEMBL5090537 | — | EC50 | = | 1930.2 | nM | 5.71 |
| CHEMBL5088559 | — | Emax | = | 0.19 | nM | - |