Assay Detail
Binding
CHEMBL5043397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Diprenorphine from human mu opiod receptor expressed in CHO cells incubated for 1 hr by competition binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.11 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083403 | — | — | 1 | 9.29 |
| CHEMBL38874 | DAMGO | — | 1 | 9.19 |
| CHEMBL2443262 | OLICERIDINE | 4.0 | 1 | 8.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083403 | — | Ki | = | 0.514 | nM | 9.29 |
| CHEMBL38874 | DAMGO | Ki | = | 0.64 | nM | 9.19 |
| CHEMBL2443262 | OLICERIDINE | Ki | = | 1.456 | nM | 8.84 |