Assay Detail
Functional
CHEMBL5043398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human mu opioid receptor expressed in HEK293 assessed as increase in calcium mobilization incubated for 60 mins by FLIPR assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.22 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083403 | — | — | 1 | 8.29 |
| CHEMBL38874 | DAMGO | — | 1 | 8.20 |
| CHEMBL2443262 | OLICERIDINE | 4.0 | 1 | 8.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083403 | — | EC50 | = | 5.09 | nM | 8.29 |
| CHEMBL38874 | DAMGO | EC50 | = | 6.38 | nM | 8.20 |
| CHEMBL2443262 | OLICERIDINE | EC50 | = | 6.7 | nM | 8.17 |