Assay Detail
Toxicity
CHEMBL5044669
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Cytotoxicity against human Jurkat cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.32 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5093832 | — | — | 1 | 6.80 |
| CHEMBL5092352 | — | — | 1 | 6.64 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.52 |
| CHEMBL5080669 | — | — | 1 | 6.48 |
| CHEMBL5077674 | — | — | 1 | 6.47 |
| CHEMBL5082644 | — | — | 1 | 6.46 |
| CHEMBL5079482 | — | — | 1 | 6.44 |
| CHEMBL5079646 | — | — | 1 | 6.25 |
| CHEMBL5070026 | — | — | 1 | 6.24 |
| CHEMBL5069541 | — | — | 1 | 6.23 |
| CHEMBL511749 | — | — | 1 | 6.21 |
| CHEMBL5076163 | — | — | 1 | 6.13 |
| CHEMBL5093602 | — | — | 1 | 5.87 |
| CHEMBL5085871 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5093832 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5092352 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5080669 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5077674 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5082644 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5079482 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5079646 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5070026 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5069541 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL511749 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5076163 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5093602 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL5085871 | — | IC50 | = | 1720.0 | nM | 5.76 |