Assay Detail
Binding
CHEMBL5046166
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Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by Z'-LYTE assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (CHEMBL5543) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective Macrocyclic Inhibitors of DYRK1A/B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.97 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5086263 | — | — | 1 | 8.30 |
| CHEMBL5089965 | — | — | 1 | 7.75 |
| CHEMBL5093741 | — | — | 1 | 7.72 |
| CHEMBL5075321 | — | — | 1 | 7.26 |
| CHEMBL5075335 | — | — | 1 | 7.16 |
| CHEMBL5081601 | — | — | 1 | 6.84 |
| CHEMBL5079894 | — | — | 1 | 6.82 |
| CHEMBL5086482 | — | — | 1 | 6.27 |
| CHEMBL5089643 | — | — | 1 | 6.03 |
| CHEMBL5088208 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5086263 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5089965 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5093741 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5075321 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5075335 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5081601 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL5079894 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5086482 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL5089643 | — | IC50 | = | 929.0 | nM | 6.03 |
| CHEMBL5088208 | — | IC50 | = | 3050.0 | nM | 5.52 |