Compound Detail
CHEMBL5079894
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Basic Information
| ChEMBL ID | CHEMBL5079894 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UXVJSLNUZNAQHS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
389.5
MW (Da)
2.97
ALogP
6
HBA
1
HBD
84.6
PSA (Ų)
0.50
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B CHEMBL5543 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B | IC50 | = | 150.0 | nM | 6.82 | Inhibition of DYRK1B (unknown origin) measured after 6 hrs in presence of ATP by... | 35450378 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 200.0 | nM | 6.7 | Inhibition of DYRK1A (unknown origin) measured after 6 hrs in presence of ATP by... | 35450378 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35450378 | 10.1021/acsmedchemlett.1c00630 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 35450378 | 10.1021/acsmedchemlett.1c00630 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | 1 |
Data from ChEMBL 36 via Core Engine