Assay Detail
Functional
CHEMBL5047794
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Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.88 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5071942 | — | — | 1 | 6.96 |
| CHEMBL5074018 | — | — | 1 | 6.70 |
| CHEMBL5091789 | — | — | 1 | 6.54 |
| CHEMBL5089561 | — | — | 1 | 6.51 |
| CHEMBL5085872 | — | — | 1 | 6.42 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 6.29 |
| CHEMBL5091543 | — | — | 1 | 6.13 |
| CHEMBL5078347 | — | — | 1 | 6.11 |
| CHEMBL5079397 | — | — | 1 | 5.89 |
| CHEMBL5076528 | — | — | 1 | 5.82 |
| CHEMBL5070586 | — | — | 1 | 5.79 |
| CHEMBL5083002 | — | — | 1 | 5.71 |
| CHEMBL5080996 | — | — | 1 | 5.66 |
| CHEMBL5071429 | — | — | 1 | 5.61 |
| CHEMBL5079231 | — | — | 1 | 5.60 |
| CHEMBL5086413 | — | — | 1 | 5.59 |
| CHEMBL5086369 | — | — | 1 | 5.57 |
| CHEMBL5093540 | — | — | 1 | 5.44 |
| CHEMBL5079887 | — | — | 1 | 5.42 |
| CHEMBL5084675 | — | — | 1 | 5.32 |
| CHEMBL5083425 | — | — | 1 | 5.21 |
| CHEMBL5085515 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5071942 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5074018 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5091789 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5089561 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5085872 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL5091543 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5078347 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5079397 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5076528 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL5070586 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL5083002 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5080996 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL5071429 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL5079231 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL5086413 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL5086369 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5093540 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL5079887 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL5084675 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL5083425 | — | IC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL5085515 | — | IC50 | = | 8040.0 | nM | 5.09 |