Assay Detail
Functional
CHEMBL5047800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1975 cells harboring EGFR L858R/T790M double mutant assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1975 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and bioevaluation of diaryl urea derivatives as potential antitumor agents for the treatment of human colorectal cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.96 | 6.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 6.94 |
| CHEMBL5071942 | — | — | 1 | 6.66 |
| CHEMBL5091543 | — | — | 1 | 6.22 |
| CHEMBL5076528 | — | — | 1 | 5.61 |
| CHEMBL5079231 | — | — | 1 | 5.54 |
| CHEMBL5093540 | — | — | 1 | 5.47 |
| CHEMBL5084675 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5071942 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL5091543 | — | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL5076528 | — | IC50 | = | 2438.0 | nM | 5.61 |
| CHEMBL5079231 | — | IC50 | = | 2883.0 | nM | 5.54 |
| CHEMBL5093540 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL5084675 | — | IC50 | = | 5454.0 | nM | 5.26 |