Assay Detail
Binding
CHEMBL5049168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of horse serum BChE by Ellman's spectrophotometric assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.69 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083613 | — | — | 1 | 6.37 |
| CHEMBL5090153 | — | — | 1 | 5.96 |
| CHEMBL3586771 | — | — | 1 | 5.96 |
| CHEMBL5083737 | — | — | 1 | 5.80 |
| CHEMBL5083014 | — | — | 1 | 5.70 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.68 |
| CHEMBL5090504 | — | — | 1 | 5.54 |
| CHEMBL4571763 | — | — | 1 | 5.47 |
| CHEMBL5078658 | — | — | 1 | 5.39 |
| CHEMBL5081663 | — | — | 1 | 5.37 |
| CHEMBL4598256 | — | — | 1 | 5.33 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083613 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5090153 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3586771 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5083737 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5083014 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5090504 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4571763 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5078658 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5081663 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4598256 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL396778 | SAFINAMIDE | IC50 | - | — | - |