Assay Detail
ADMET
CHEMBL5049182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP3A4 expressed in baculosomes by fluorescent homogenous assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.92 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.60 |
| CHEMBL5083737 | — | — | 1 | 6.22 |
| CHEMBL5081574 | — | — | 1 | 6.10 |
| CHEMBL5090153 | — | — | 1 | 5.46 |
| CHEMBL3586771 | — | — | 1 | 5.16 |
| CHEMBL5082824 | — | — | 1 | 5.00 |
| CHEMBL5072382 | — | — | 1 | - |
| CHEMBL4464759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5083737 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5081574 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5090153 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3586771 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5082824 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5072382 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4464759 | — | IC50 | > | 10000.0 | nM | - |